ABC Transporters and Multidrug Resistance (Wiley Series in by Ahcene Boumendjel, Jean Boutonnat, Jacques Robert

By Ahcene Boumendjel, Jean Boutonnat, Jacques Robert

A accomplished evaluate of the most up-tp-date clinical study on ABC transporters and multidrug resistanceATP-binding cassette transporter genes (ABC transporters) are recognized to play a vital function within the improvement of multidrug resistance (MDR). MDR is the power of pathologic cells, reminiscent of tumors, to resist chemical compounds designed to focus on and wreck such cells. In MDR, sufferers who're on drugs finally increase resistance not to purely the drug they're taking, yet to a number of varieties of drugs.ABC Transporters and Multidrug Resistance bargains an important source for pharmaceutical researchers who're operating to find medicinal drugs to counteract multidrug resistance in ailments comparable to melanoma. in a single finished quantity, this e-book includes a selection of the most up-tp-date wisdom at the involvement of ABC transporters in drug delivery and resistance.This accomplished quantity offers an summary at the description of the constitution, the genome, general tissue expression, physiological element, and mechanism of motion of the ABC protein. The professional participants discover the expression, detection, and implications of ABC proteins in hematological malignancies and sturdy tumors and ABC proteins and pathogenic microorganisms. This quantity additionally explains MDR modulation via inhibition of ABC transporters and the layout of inhibitors and mechanism of motion. furthermore, the ebook deals crucial info at the organic and scientific point of multidrug resistance.

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2005. Differential regulation of MDR1 transcription by the p53 family members. Role of the DNA binding domain. J Biol Chem 280: 13213–13219. 38. Okamura H, Yoshida K, Sasaki E, Morimoto H, and Haneji T. 2004. Transcription factor NF-Y regulates mdr1 expression through binding to inverted CCAAT sequence in drug-resistant human squamous carcinoma cells. Int J Oncol 25: 1031–1037. 39. Chen GK, Sale S, Tan T, Ermoian RP, and Sikic BI. 2004. CCAAT/enhancerbinding protein beta (nuclear factor for interleukin 6) transactivates the human MDR1 gene by interaction with an inverted CCAAT box in human cancer cells.

Johnson RA, Shepard EM, and Scotto KW. 2005. Differential regulation of MDR1 transcription by the p53 family members. Role of the DNA binding domain. J Biol Chem 280: 13213–13219. 38. Okamura H, Yoshida K, Sasaki E, Morimoto H, and Haneji T. 2004. Transcription factor NF-Y regulates mdr1 expression through binding to inverted CCAAT sequence in drug-resistant human squamous carcinoma cells. Int J Oncol 25: 1031–1037. 39. Chen GK, Sale S, Tan T, Ermoian RP, and Sikic BI. 2004. CCAAT/enhancerbinding protein beta (nuclear factor for interleukin 6) transactivates the human MDR1 gene by interaction with an inverted CCAAT box in human cancer cells.

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