Adipokines by Victor R. Preedy, Ross J. Hunter

By Victor R. Preedy, Ross J. Hunter

Adipokines (also referred to as adipocytokines) are a bunch of peptides secreted through adipose tissue. they've got various roles, from capabilities within the person mobile to the complete physique. This quantity examines quite a lot of particular adipokines in addition to their basic mobile elements, together with thermal rigidity and adipokine expression, valuable worried approach roles for adiponectin in neuroendocrine and autonomic functionality, and astroglial leptin receptors. It discusses comparable ailments and stipulations akin to nonalcoholic fatty liver sickness, metabolic syndrome, center and rheumatic ailments, and bronchial asthma and sleep problems.

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Obes. Relat. Metab. Disord. 24 Suppl. 2: S142-143. Massiera, F. and M. Bloch-Faure, D. Ceiler, K. Murakami, A. M. Gasc, A. Quignard-Boulange, R. Negrel, G. Ailhaud, J. Seydoux, et al. 2001a. Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J. 15: 2727-2729. Massiera, F. and J. Seydoux, A. Geloen, A. Quignard-Boulange, S. Turban, P. Saint-Marc, A. Fukamizu, R. Negrel, G. Ailhaud, and M. Teboul. 2001b. Angiotensinogen-deficient mice exhibit impairment of diet-induced weight gain with alteration in adipose tissue development and increased locomotor activity.

The complex of calcitonin receptor-like receptor and receptor activity-modifying protein-2 or -3 generate adrenomedullin receptor, a seven trans-membrane domains receptor protein. ADIPOSE TISSUE AND ADRENOMEDULLIN AT has recently been considered to play an active endocrine and paracrine role. In fact, the adipocyte is an active organ that secretes a variety of bioactive molecules, named adipokines, which are directly and indirectly related to metabolic and cardiovascular diseases, such as diabetes mellitus, obesity, hypertension and coronary artery disease.

A strong relationship exists between adipocyte-secreted apelin and insulin (Castan-Laurell et al. 2005). Adipocyte apelin mRNA expression and plasma apelin concentrations were increased in various mouse models of obesity associated with hyperinsulinemia. Accordingly, adipocytes of insulin-deficient mice (streptozocin-treated) had lower apelin mRNA levels than controls (CastanLaurell et al. 2005). Direct action of insulin in the regulation of apelin expression in adipocytes was also shown in vivo.

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